Dermatofibrosarcoma

Dermatofibrosarcoma Protuberans.  

These lesions are slow growing nodules that may occur at the site of trauma.  They rarely metastasise and generally just grow locally.  They often extend some distance beyond what is clinically apparent.  The lesions presents as a dermal tumour as a nodule.  There are usually uniform small spindle cells with plump nuclei and may be arranged in what is called a storiform pattern.  They can infiltrate fat in a honeycomb pattern.  There is usually thinning of the overlying epidermal rete ridges and you may get layers of fibrous tissue in the fat, that range parallel to the overlying epidermis.  A pigmented variant of DFSP is the Bednar tumour. In this the dendritic cells contain melanin and it may stain with S100.  It particularly occurs in young women on the trunk and has never been known to metastasise.  The melanin is probably due to colonisation of the DFSP by melanocytes.

Look at the presentation below and then view these Virtual Slides

DFSP       DFSP 2     DFSP 3