Sebaceous lesions are commonly biopsied because they can look like BCCs. Sebaceous hyperplasia is usually multiple on the forehead but sebaceous adenomas and carcinoma are often solitary lesions around the eyelids and can be difficult to diagnose clinically. Dermatoscopy can help but sebaceous carcinoma can look very like a BCC under the dermatoscope as well!
Look at the Presentation below then View these Virtual Slides
Sebaceoma - mixture of basaloid cells peripherally in lobule with central sebocytes.
Loss of normal nuclear staining for MSH2 or MLH1 suggests microsatellite instability and possibility of Muir Torre syndrome
Sebaceous carcinoma - more atypical sebocytes with scalloped nuclei, mitoses and infiltrative border, occassionally Pagetoid in epidermis
When you have finished this video go to Barnhill's Dermatopathology Challenge Page 579 and work your way through the questions to assess what you have learned from this presentation.
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